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  1. #241
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    Hi everyone - I'm fairly new to this site, and don't understand the acronyms so will write it all out longhand, if that's ok.

    My specialist prescribed DHEA for poor egg quality 6 weeks ahead of my second IVF-ICSI cycle. I had what can best be described as continual panic attacks and a couple of 'episodes' of feeling extreme anxiety, followed by a draining feeling and feeling like passing out. This only happened in the first two weeks of taking DHEA, and when I mentioned it to my specialist, she dismissed it having anything to do with DHEA. What total crap. I decided to continue taking it, but unfortunately, it didn't appear to have much effect on my eggs. My second ICSI cycle resulted in only 3 mature eggs, none of which fertilised (they apparently were very 'oozy' when injected). Just gutted. My specialist told us that given the poor egg quality it's highly unlikely we'll have kids of our own. Still trying to process that .... I convinced her we'd like to give it one more try in October this year, with a break of 4 months to (hopefully) give some of the crap eggs a chance to cycle through and produce some better ones. I'll continue on DHEA during that time ... maybe a longer exposure to the drug will produce a better result. I'm taking 75mg per day.

    God, at this stage, I'm willing to try just about anything .. the thought of not having a child to love, and teach things to is just heartbreaking. My husband would make a brilliant dad, and I'd like to think I'd make a good mum.

    This is one of the most soul destroying things I have ever done, and the odds are stacked against me. To add insult to injury, I appear to have picked up an infection after the second egg pick up, which resulted in excruciating pain for the best part of a week. My GP put me on Oxycontin to try and get the pain back under control, and my specialist didn't really acknowledge it may have come from the egg collection procedure and just handed me a script for an antibiotic. The pain lessened fairly quickly, so I guess that was the problem.

    Sorry for rambling -- I've had a really crappy week and am over bursting into tears all the time. It feels good to vent to other ladies going through the same ups and downs.

    Good luck everyone!

    _________

    I am 40, my Husband is 35
    1st IVF-ICSI cycle --> 5 mature eggs, 1 fertilised; transferred as 3 day embryo but it didn't stick the landing
    2nd IVF-ICSI cycle --> 3 mature eggs, none fertilised.
    Told we'll never have kids of our own, but one more try lined up for October

  2. #242
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    Trying to get by - I'm really sorry to read your post. It's absolutely heart breaking to hear those words. It's sounds like you have an issue with egg maturity as well as quality. I did dhea for 3 months and I think it helped. But I also feel a few other things helped. I was on a higher dose of gonal-f and we used a protocol that included "add back" which is low dose pregnyl shots during the stim phase. My blood tests showed that my LH hormone was normal but FS agreed to use add back anyway. I think it helped as 8 out of 9 eggs were mature vs 4 out of 12 mature previous cycle. I was also on coq10 for the 3 months and stimmed for a few days longer to ensure the lead follicle was a good size and e2 levels were high.

    Unfortunately that last cycle ended in miscarriage but I will cycle again in November and we will see what happens. I intend to up my gonal-f to at least 150ius next time. I have pcos so it's hard for my FS to gauge, but I think the higher dose will help get a few more eggs and hopefully the add back, dhea and coq10 will help with quality.

    Good luck.

  3. #243
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    Hello Trying To Get By , welcome to Bubhub . I’ve been on DHEA for 4 months now (I was on it for 3 months late last year and had a break and decided to try it again). I do remember in the beginning I did experience the feeling of anxiety, but thankfully it didn’t last long. I do believe it was related to taking DHEA until my body got used to it.

    You mentioned that you took DHEA for 6 weeks ahead of your second IVF/ICSI cycle, I have read that to take real effect, you should take it for at least 3 months. It is not recommended to take it for a long period of time (I think my 4 months is more than enough). So, yes, I agree with you 100% when you say taking it longer may produce a better result. This is due to the egg taking 3 months to mature before it is released (or something along those lines) . I am taking 75mg per day too (3 x 25mg).

    Your story is so touching, I really feel for you . I’m hoping so much that being longer on DHEA will help your egg quality. I know it helped me out. In August last year I had only 2 eggs at pick up and they were both crap quality they couldn’t even be fertilised. So I tried DHEA for 3 months and when I had my next egg pick up in February this year I had 3 eggs but guess what, they all fertilised and I had 2 embryos put back in (the third one wasn’t that great to freeze in the end). I believe I would have fallen pregnant with at least one of these embryos if I didn’t drink pineapple juice (this is a BIG no no after embryo transfer, as the acid inhibits implantation, gee I was angry at myself when I found this out, I’m still not over it).

    Your story is not that uncommon, I have read stories from ladies with poor egg quality who have gone on to have a baby, so there is still hope for you, that’s for sure . Not sure how many stories you’ve read from this thread but I would really recommend you reading some from women who have conceived with poor egg quality and took DHEA.

    I would like to suggest you see a new specialist. Of course I don’t know your situation so I apologise if I’m out of line, but your current specialist doesn’t sound very proactive in helping you, I mean dismissing the DHEA as being the cause of your anxiety/panic attacks and then not acknowledging your pain after egg pick up being related to the having the egg pick up doesn’t seem very fair or compassionate to me, then to top things off she said to you it is highly unlikely you’ll have kids of your own .

    As I said, I don’t want to offend, I just would love to see you get the best possible assistance and care to help you achieve your dream of having a child, she sounds mean to me, no wonder you’re bursting into tears. You deserve better .

    PS - if you would like a list of abbreviations, let me know
    Last edited by AceOfBase; 02-07-2012 at 20:44.

  4. #244
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    DHEA didn't seem to work for me. I took it for 6.5 months. My first IVF was a standard Gonal Antagonist cycle, I only got 2 eggs so converted to IUI and got a chem preg. The second month after I tried IVF with a flare cycle. I was forced to have a new FS as my current one had left the clinic. The new FS refused to renew myDHEA script two weeks before I commenced the cycle. I got 5 eggs but only one was fertilisable and BFN although I believe it was another chem preg. I was on 75mg of DHEA for the whole time I took it. Based on the results I'd say it didnt work for me, I think the increased numbers were due to the flare cycle. I do know someone else of similar age whose egg numbers went from 2 - 6 with better results after a similar time on DHEA.
    MumtoChris. Fresh pineapple contains bromelain which is supposed to help implantation. I've never heard of it being a bad thing before. i'm really sorry for your experience.

  5. #245
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    Hi Net3811 – Sorry to hear DHEA didn’t work for you, I hope you get your BFP real soon . Yes, I thought the same thing about pineapple, which is why I drunk pineapple juice for the entire TWW, but it’s the core that contains bromelain and eating/drinking the flesh is not allowed. This website explained it to me better http://www.amandabears.com/pineapple...lantation.html which of course I found out AFTER my BFN. Anyway, for this current cycle I’m cutting out the pineapple core, slicing it into 5 pieces and eating 1 piece a day for 5 days after ET. I hope I get it right this time.
    Last edited by AceOfBase; 02-07-2012 at 22:03.

  6. #246
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    Hi, me again. Just went back to the website I posted and they now require a login to enter the site, which is free, just annoying we have to sign up. I might sign up again because I did find the info useful.

  7. #247
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    Hello there "Trying to get by"

    I havent been into this forum for some time but something made me pop in tonight and I have just read you story...it sounds exactly the same as mine! BUT, I am now 26 weeks pregnant and just want to let you know that you can't let that FS get to you and destroy any hope of your dream coming true. I wonder if you are seeing the FS I started out with as she told us the exact same thing so we changed FS...are you in Melbourne? When I started on DHEA it made me "lose the plot" and so I stopped taking it and when I explained that to that FS, she said it was not the DHEA...I didn't beleive her. When i started with new clinic and FS, he suggested DHEA but from a different pharmacy who had given other patients miracle babies...DH and I decided to give it a go. Our FS said we needed to be on it for at least 5 months to really see results...well, we did and although our last round of IVF did not result in pregnancy, we did have our 1 and only "extra" which is now on ice BUT while we were waiting to have that embie implanted...I conceived naturally! I am the 3rd of his recent patients for this to happen to and we had all been told we had less than 1% chance of conceiving. PLEASE do not lose hope! I am 40 and DH is 32...I wish you all the luck in the world that your dream will one day come true.

    Baby dust sent to you...XXXX

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  9. #248
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    I'll write on here tomorrow

  10. #249
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    Thank you so much ladies -- your kind thoughts and stories of support have reduced me to tears. Through this process I have felt fairly alone -- it's comforting to know there are others out there in a similar situation, and I wish everyone the very best.

    Nicole83 - My last IVF-ICSI cycle I took 300 units of Puregon, with 50 units of Pregnyl every second day, and Ovidrel as the trigger, plus the 75mg of DHEA ... resulting in three crap eggs that didn't fertilise. I had also completely changed my diet -- given up fast food, processed sugars and chocolate, alcohol; started taking fresh juices daily with a shot of wheatgrass. I'd lost around 5 kilos (I'm a little heavier than I used to be, but not fat by any stretch), still to no avail. I had even tried acupuncture just before the egg removal ('pick up' sounds too casual for what is involved) and am taking Chinese herbs prescribed by a TCM Practitioner/Naturopath who has been recommended to me.

    To be honest, I am completely confused -- my FSH is 5, which is apparently good, yet my eggs are crap. Hoping that longer exposure to DHEA will improve things. In my heart I am hoping it will only take some tweaking before I am back on track. No history of infertility in the family (certainly not on my mum's side -- she had my younger brother a month off 39 years).

    I'm curious about CoQ10 .. I've never read about it being used for fertility treatment before now, and it's not something my specialist had suggested. I'll look into it - thanks!

    Mummyhopes/mumtochris - I'm in Canberra, and my specialist is widely thought of as one of the best (and she definitely has the best pregnancy rates) .. she is a little blunt though. I am a bit annoyed at the way she talked to us at our last appt .. we said we'd been doing some heavy Googling on things that may help and she said "if you find anything of use, let me know" -- kinda thought we were paying her to do that research for us! I am considering a second opinion, based on the info in my file -- this is too important to just accept it without testing it. There is only one chemist in town that stocks and compounds DHEA, so there aren't other options, but given the anxiety effects it has had early on, I'm sure it's doing something! So pleased it has worked for others - all the very best!

    Again, thanks so much ladies -- having your support means more than I can say xx

  11. #250
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    Hi all

    This is my first post to this thread. I have been taking DHEA for 8 months approx. My dosage is 75 (3 tablets). some info on dhea that I found:
    http://haveababy.blogspot.com.au/search?q=dhea

    My integrative Doc wants me to go off the DHEA so that he can establish a baseline. He thinks that I have too much DHEA which has started to convert to oestrogen and which in turn can be pretty harmful (cancer causing) and due to a hormonal imbalance be counterproductive to my fertility. My only hesitation is that it takes so long for DHEa levels to get established (3-4 months according to my FS) before it is effective that I don't want this to set me back. On the other hand an overdose is probably making me infertile. So confusing!!!!!! Has anyone had any experience with this?


 

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