46 Male, 2 kids, had depression and anxiety for nearly 20 years, tried all forms of prescribed medication, and years and years of therapy.
All this was going on while running my own company.
5 years ago my GP retired and had to find another one. She looked at my meds and my history and shook her head. It took about a week to be weaned off my old AD's and I went on Effexor (150mg nightly). She also put me on 10mg Neulactil to help with sleeping.
That first week I had the best night sleeps that I could remember, and after about 3 weeks the Effexor kicked in and it was about 3 months after that the anxiety/panic attacks evaporated.
In that three months, my depression represented itself, but at a milder level. My GP increased the dosage to 150mg nightly, where I have stayed ever since. My neulactil is 2.5mg nightly, and I have tried several times to come off them but, but as yet no success.
In summary, I cannot remember the last time I've had a panic attack. Its been years. My quality of life has turned around so much that my family and friends cannot remember me being so 'normal' for so long.
My fear of relapse is a distant memory.
After 20 years with this, all I can state is that not every medication is right for the same person, it takes patience and a will to work out the right combination. It also takes an experienced GP to assist.