After Help or Information on Heterozygote.

[Leeny]

I hope im putting this in the correct place. Im wondering if anyone has ever heard of Heterozygote - Leader Factor 5. I've searched the forums for heterozygote and leader factor 5 but im not getting anything on it. Does anyone know if its the same as "factor 5" That i've seen a few people talk about in a thread about blood clots?

Im only asking because apparently its genetic, and i've been told to be tested for it, as many women in the family have it, and im meant to be in the group which needs to be tested. I know nothing about it, and i've searched quite a bit online....Just hoping someone else has heard of it and can give me some insight. Thanx :):)

[blessedmummy]

hey! just googled it and it came up as being for example someone who has inherited both carrier genes for some illness or something... depending on what it is really... just means two genes that are carrier genes..if that makes sense! hope this helps! :fingerscrossed:

[Leeny]

Thanx alot for that :D...Cant believe i missed it :eek:

[janco]

Hi there,
I just came accross this post and I wanted to suggest that maybe you have been told to be tested for Factor 5 Leiden - usually written as "Factor V Leiden". This is a hereditary blood condition which makes you more likely to develop blood clots.
If you do a google search for this condition you will find heaps of info - Hope that helps.

[Leeny]

Thats it! Thats the exact reason that i was told, as a few family members have died from clots. Thanx so much janco, you're wondeful :)

Oh and welcome to bubhub :)

[mum23girls]

Not knowing anything about it... but would asprin help?

[Leeny]

Not knowing anything about it... but would asprin help?

Good idea, i have no idea about it yet, i was reading a fair amount last night. Its apparently a gene thats inherited from either 1 parent or both, if its 1 parent, the chances of getting a thrombosis(sp?) is very rare, and if its handed down by both parents, the chances go up. I read that ever if you had the gene from both parents, there may never be any medical issue, they said our of 100 people, only a small minority had problems.

I also read that unless you're tested specifically for it, theres no symptoms until you actually get the clot.

It sounds like a relative trying to worry us over something thats so unlikely:rolleyes: I know my great grandma had it, but she had lots of other problems aswell, and i know alot of other women in the family have it. Ahh, it just seems so silly to worry over something so trivial. God forbid, i could have a fatal car crash tomorrow:eek:

[mum23girls]

Well, hope you don't have it an live to a ripe old age of 110!!! :fingerscrossed: Are you going to get tested?

[PMS]

Hiya. I have the Factor V gene; heterozygous (only one gene not two). Hasnt made any difference to my life except that after I had DS I had to have Heparin injections and doc just kept an eye on me..... It is hard to find information on Factor V that is actually easy to understand.... chances are that you'll have the blood test and not have the gene. Most of the females in my family have it but my younger sister doesnt; go figure..........
Best wishes what ever you do......

[Leeny]

Thanx guys, i honestly dont think i will have the test. My mum had 2 kids before she knew about it, and i had dd before i found out about it. If i had it, i would assume that i've already been put at risk and i was fine?...I'll just let sleeping dogs lie...No need worrying over trivial stuff i guess :D

[Luna Lovegood]

Thanx guys, i honestly dont think i will have the test. My mum had 2 kids before she knew about it, and i had dd before i found out about it. If i had it, i would assume that i've already been put at risk and i was fine?...I'll just let sleeping dogs lie...No need worrying over trivial stuff i guess :D

I found out I have Factor V Leiden whilst pregnant, and it actually leads to life threatening conditions.
· I have just been diagnosed with my third occlusive DVT, in 10 months; I have spent 2 months in a wheelchair, 3 months in hospital and live in constant pain.
· Thrombosis can lead to amputation of the limbs.
· Pulmonary embolisms ARE FATAL, and with no warning, or indication.
· Strokes ARE FATAL
· I have had my gall bladder removed this year as well, as a result of factor V Leiden
· Pregnancy increases the hormones in your body, which increases your chance of clotting dramatically- as does the pill, implanion, and most other forms of contraception.
· Whilst pregnant you have a higher chance of miscarriage due to blood clots in the placenta, removing oxygen from the foetus
· Your chance of birthing a deceased child increases due to the above reason as well.
· As you get older the chances of clotting increases dramatically
· Once you have thrombosis, the chances of recurrent thrombosis is very high, as well as the integrity of your veins decreases with time.
BUT if the condition is known about it can be monitored, and is therefore less severe.
· Small doses of aspirin on a daily basis
· Whilst pregnant it may be necessary to have Clexane (low weight molecular heparin) BD on a 12hr turn around.
· During labour you may need to have a scheduled laboured to monitor your blood flow and how "thin" you blood is, in risk of haemorrhaging. A heparin fusion maybe required at some stage afterwards to prevent post partum clotting.
· Warfarin is used for non-pregnant ladies for thrombosis (and also heart conditions). This requires close monitoring with frequent blood tests (every two days- once a week) to maintain a therapeutic INR.
· Pressure stockings must be worn for flight.
· In the event of surgery if you have been using anticoagulants you may be required to have white blood cell transfusions to prevent haemorrhaging.
Your blood is your lifeline, far from trivial stuff. I value my life way too much to let resting dogs lie. Health is so often neglected due to laziness, and the people who it affects sit there wondering "why me?"

All of my paternal family have been diagnosed with it and no one knew about it until I was diagnosed- and most of the females have had kids. But as they are all reaching their 40's/50's it is something they should be wary of.

I also recommend not smoking, binge consumption of alcohol, and ensuring you body is hydrated at all times (your blood is 70% water)

So what if you’re never affected by it, at least you know you have to be careful.

[Oh So Ready!]

Hi there to you all
I have no children yet but I do have Factor V Leiden it is genetic and the funny thing is I was told about it and I got tested, (It came back negative) about a year later after taking the pill for the whole time i formed a clot (I was 19) now because of this i will have to have clexane injections during pregnancy, it can be serious however my mum and both my sisters who successfully had children without clotting have all (except one) fomred them in later life. From what i have been told you are at greater risk if you have already had a clot, are a smoker, if you drink a fair bit or if you are over weight (which I am). I am not writing this to scare you ar anything but please be careful. And remember my tests came up negative before i got my clot. Hope this helps.

[licorice]

Heterozygote (as some one has said previously) is one gene change not 2

Homozygote is having two of the same gene changes

Compound heterozygote means that you have 2 different gene changes in the same gene