Panadol before vaccination?

[dad2bee]

Some information, I haven't read he lancet study yet.

http://cme.medscape.com/viewarticle/711230?src=cmenews&uac=119061ER

[Seekrit]

I haven't read any studies, but I refuse to give panadol before symptoms appear... I won't take a couple of panadol myself in anticipation of a headache.. you know?

It can mask the immediate allergic reactions, and can be completely unnecessary. My son's reaction was a fever about 4-6 hours after the event so giving him panadol would've been useless, my daughter so far has had no reaction.. so giving to her would be dosing her for no reason at all.

(ps - your site requres a password)

[CheekyChicken]

I can't see it.

Would like to add that panadol should only be used on little ones with a high fever. Panadol use while young can cause athsma in later life.

[Fuchsia!]

Not sure what the the site says, you need a password.

I was watching the new a few weeks ago and they are now not recommending it.

I wouldn't anyway, same reasons as Seekreet plus i don't give my children panadol unless absoluely needed which is very rare. Panadol come with their own yucky risks.

[dad2bee]

Sorry

October 26, 2009 — Prophylactic administration of acetaminophen (paracetamol) to reduce fever or febrile convulsions after vaccination in infants actually results in reduced immunogenicity and should not be routinely recommended, according to a new study published in the October 17 issue of The Lancet.

"Although fever is part of the normal inflammatory process after immunization, prophylactic antipyretic drugs are sometimes recommended to allay concerns of high fever and febrile convulsion," write Roman Prymula, MD, from the University of Defence, Hradec Kralove, Czech Republic, and colleagues. "Evidence lending support to this approach is scarce; the level of fever is unrelated to the onset of convulsion, and antipyretic drugs are ineffective in prevention of benign febrile convulsion in children who are at risk."

The aim of the study was to assess the effect of acetaminophen on infant febrile reaction rates and vaccine responses.

Vaccination Open-Label Studies Performed

The authors performed 2 consecutive (primary and booster) vaccination open-label studies. Healthy infants aged 9 to 16 weeks were randomly assigned to receive 3 prophylactic acetaminophen doses every 6 to 8 hours in the first 24 hours (n = 226 infants) or to no acetaminophen (n = 233 infants) after each vaccination with a 10-valent pneumococcal nontypeable Haemophilus influenzae protein D-conjugate vaccine (PHiD-CV) coadministered with the hexavalent diphtheria-tetanus-3-component acellular pertussis-hepatitis B-inactivated poliovirus types 1, 2, and 3-H influenzae type b (DTPa-HBV-IPV/Hib) and oral human rotavirus vaccines.

Prophylactic acetaminophen did reduce febrile reactions, the investigators report. The percentage of children with a temperature of 38ºC or greater after at least 1 dose was significantly lower in the prophylactic acetaminophen group after primary vaccination (94/226; 42%) and after booster (64/178; 36%) vs the no-prophylactic acetaminophen group after primary vaccination (154/233; 66%) and after booster (100/172; 58%). Fever greater than 39.5ºC was uncommon in both groups.

Unexpected Finding Reported

However, an unexpected finding was a substantial reduction in the primary antibody response to each of the 10 pneumococcal conjugate vaccine serotypes and to Hib polysaccharide, diphtheria, tetanus, and pertactin antigens. "After boosting, lower antibody GMCs persisted in the prophylactic...[acetaminophen] group for antitetanus, protein D, and all pneumococcal serotypes except for 19F," the study authors write.

"To our knowledge, such an effect of prophylactic...[acetaminophen] on postimmunisation immune responses has not been documented before. Remarkably few published studies have assessed the effects of antipyretic drugs on child vaccine responses," Dr. Prymula and colleagues write.

They conclude that the clinical relevance of their findings is unknown and needs further assessment but suggest that the prophylactic administration of antipyretic drugs at the time of vaccination "should nevertheless no longer be routinely recommended without careful weighing of the expected benefits and risks."

[Fuchsia!]

I was just coming back to say that i remember WHY they didn't recommend it and its what you have said above that it interacts with the vaccine.