Liver damage from Losec?

[kotakai]

Just wondering if anyone has had any liver damage caused by Losec? DS3 has had his Losec dose increased yesterday, as he's still having probs, but his paed wants him to have a liver function test just to be sure, as he says he's on a high dose. Not sure if he means his age or weight or because he was prem that the dose is high.

So my question is, has your bub had liver damage & if so what dose were they on?

[Nowhere]

DD has had liver damage, some vakues of her LFT have been out but hers is most likely from her time on perantal nutrition and the huge amounts of meds she is on Losec is one of the drugs she is on but her drs say with her its a combination of them all,

DD is 8 kilos and is on 20 mgs of losec a day.
When she was a baby and before her fundo and drain she was on 40mg of losec a day and then 30mg a day but we tested the acidity of her reflux on both 30 and 20 mg and it was the same as we went back t0 20mg.

[Eboniesmum]

Hi,

Losec dosage is 1mg per kilo of body weight - usually
My DS is 12 weeks old today and is on 5mg of losec and he was 5.8 kilo's when he was put on that dose, he had his liver function test last week and i havent heard from the paed so im guessing it was all fine but i will ring on Monday just to make sure.

The paed said sometimes their little bodies cant handle the Losec. He also said if 5mg isnt working then give him 7.5mg but i'm hesitant to give him that much as he is nowhere near 7.5 kg's. I was also told i can give ds some mylanta

What dose is cruz on and how much does he weigh?

[kiwibird27]

DD has Cirroshsis of the liver and is on 10mg losec a day.... she needs it and the doctors don't seem too concerned about long term issues

[Nowhere]

Hi,

Losec dosage is 1mg per kilo of body weight - usually
My DS is 12 weeks old today and is on 5mg of losec and he was 5.8 kilo's when he was put on that dose, he had his liver function test last week and i havent heard from the paed so im guessing it was all fine but i will ring on Monday just to make sure.

The paed said sometimes their little bodies cant handle the Losec. He also said if 5mg isnt working then give him 7.5mg but i'm hesitant to give him that much as he is nowhere near 7.5 kg's. I was also told i can give ds some mylanta

What dose is cruz on and how much does he weigh?


losec isnt a weight determind med, it is dosed at the lowest dose to do what it needs to do, KWIM they start low if need to they up it, but its not a weight guided dosage KWIM

[reAllytee]

G was in hospital when they started him on a large dosage as he was in a bad way at 6mths.

His dosage was 30mg ( 10mg morning - 20mg nite ) he weighed approx 8kgs but was always gaining & losing due to issues ( although I am grateful for that weight thats for sure ! ) & it stayed on that dosage until he was 14mths when we managed to get him to go down to 20mgs & since then we brought it down to 10mgs ( he is a few days off 2yrs ).

He is also on Zantac which is still at the 3mls twice a day ( morning & nite ) he was started on this dose in hospital also as smaller dosages were never enough & so far we still have no success reducing the amount but we will get there !

[Eboniesmum]

losec isnt a weight determind med, it is dosed at the lowest dose to do what it needs to do, KWIM they start low if need to they up it, but its not a weight guided dosage KWIM


2 Paediatricians and a GP told me that they go off weight for Losec dosage
I suppose its not strict on that though as some babies need more, the weight thing is probably a guide and they start at the dose thats right for the weight then go up from there if need be

[Nowhere]

2 Paediatricians and a GP told me that they go off weight for Losec dosage
I suppose its not strict on that though as some babies need more, the weight thing is probably a guide and they start at the dose thats right for the weight then go up from there if need be


wow intersting must be something DDs gastrointerology team dont know about then. DD is on 20 mg a day now and is 8 kilos as a Baby in hospital she was on 40mg at one point.

[Eboniesmum]

Mikenzees mum - yeah i think they like to stick to the smallest amount possible because the poor little bubs liver may not be able to cope with it thats why they refer to their medical guide for the general dosage but if that dosage isnt helping the bub then they have no choice but to up the dose, it may also be something that the Paed's and GP's worry about more then the gastroenterology team does

[Nowhere]

Mikenzees mum - yeah i think they like to stick to the smallest amount possible because the poor little bubs liver may not be able to cope with it thats why they refer to their medical guide for the general dosage but if that dosage isnt helping the bub then they have no choice but to up the dose, it may also be something that the Paed's and GP's worry about more then the gastroenterology team does

There isnt actualy any aproved dose for losec for bubs under the age of 2 KWIM its not FDA aproved but it i used world wide in babies with reflux. Which makes it hard to dose it KWIM hense why they start at a low dose and them up it if it needs be. Im not sure about if GPs or pead wory more about that suff or not we dont see a GP for DD and our pead leaves all the GI stuf up to the GI team who are also the liver specialists.

I know that a high dose isnt optimal which is why starting lower is always the way to go.

[Eboniesmum]

oh well i dunno why the paeds and gp told me that then, i seen them with some book that they got the dosage out of, its a book of all different meds and dosages and when they looked at that they told me the dosage

[Nowhere]

oh well i dunno why the paeds and gp told me that then, i seen them with some book that they got the dosage out of, its a book of all different meds and dosages and when they looked at that they told me the dosage


I gues all drs do things diferntly hey, I wasnt trying to argue with you.

[kotakai]

Thanks for all the replies. It seems a lot of bubs are on a much higher dose than Cruz. The most Chais was ever on was 20mg, & I'm hoping Cruz doesn't need to get to that.

I just went & looked at the LFT referral & it says on losec & prem, so I guess it's the prem part he's worried about?????


Ebonie'smum- He's 4.6kgs & now on 10mg a day. 5 in the morning & 5 at night. This only started yesterday, so hopefully not too much longer & we'll see some results.

[scarlet]

Hi there, my son is on losec 30g a day and has been for 4 years now and we have seen no liver damage. Although some kids do have liver damage most of these kids have a little more going on than reflux and there is no correlation to this and losec.

Though I do think it is good to have bloods done BEFORE starting high doses of meds so at least you have a base line. My sons bloods are done every year at least for liver and kidney damage and usually every couple of months for other stuff he has going on.

I do want to add though, that with the dosing that there isn't an actual formula for dosage. Most research suggests that children need the same if not more of a dose than an adult. And this is because of the mechanism of the drug.

It isn't based on weight, it isn't distributed though the blood stream, but absorbed at the site of acid production, a child can actually produce more acid than an adult so they need a higher dose. The medication acts to stop these proton (or acid producing) pumps.

Though I totally agree that the smallest dose to get the job done, you will find, especially as they are older and start eating etc... and more acid is produced the dosing would be a lot more than 1mg/kg for most children.

The dosing guide book, is just a guide, it is at the drs discretion to dose this medicine, as a previous poster has mentioned losec has only just been approved in children one and over (previously it was 2 and over), so anything given to a child under that is considered off label.

Parker was 9kgs when we started on 30mg and is 19kgs now and still on the same dose.

Though some drs do find this a high dose (though both our paed and paed GI agree), my sons esophegous would be totally damaged (not to mention his eating aversion, ear infections, apnea, FTT and so on) if it wasn't at this dose (as would others) so sticking to a 'guide' can be harmful to some kids, which is why I wanted to point it out that it isn't cut and dried. If the dose isn't working, then make sure to push a dr for some answers like increased meds..testing etc... your child does not have to be in pain all the time.

Good luck with the testing, I hope all is fine!

[Eboniesmum]

mikenzees mum - All good, yeah all docs do things different, good to know that losec doesnt have to be dosed on 1mg per kilo of body weight cos now im not so worried about upping lucas's dose. Thanks
Kotakai - Maybe thats what we need to do to Lucas cos 5mg just isnt working. I think Lucas would roughly be about 6.5kg's now. Good luck hope 10mg works for Cruz and hope his liver test is ok